Invasive and Noninvasive Nonfunctioning Gonadotroph Pituitary Tumors Differ in DNA Methylation Level of LINE-1 Repetitive Elements

Invasive and Noninvasive Nonfunctioning Gonadotroph Pituitary Tumors Differ in DNA Methylation Level of LINE-1 Repetitive Elements

Purpose: Epigenetic dysregulation plays a role in pituitary tumor pathogenesis. Some differences in DNA methylation were observed between invasive and noninvasive nonfunctioning gonadotroph tumors. This study sought to determine the role of DNA methylation changes in repetitive LINE-1 elements in no...

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Bibliographic Details
Main Authors: Natalia Rusetska, Paulina Kober, Sylwia Katarzyna Król, Joanna Boresowicz, Maria Maksymowicz, Jacek Kunicki, Wiesław Bonicki, Mateusz Bujko
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Journal of Clinical Medicine
Subjects:
DNA methylation
LINE-1
L1-ORF1p
pituitary tumor
gonadotropinoma
invasive growth
Online Access:https://www.mdpi.com/2077-0383/10/4/560

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https://www.mdpi.com/2077-0383/10/4/560

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