Itraconazole Amorphous Solid Dispersion Tablets: Formulation and Compaction Process Optimization Using Quality by Design Principles and Tools
BCS Class II drugs, such as itraconazole (ITZ), exhibit poor solubility (1–4 ng/mL) and so require solubility enhancement. Therefore, ITZ and Kollidon<sup>®</sup> VA64 (KOL) amorphous solid dispersions (ASDs) were produced using hot-melt extrusion (HME) to improve ITZ’s poor solubility....
Главные авторы: | , , , , |
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Формат: | Статья |
Язык: | English |
Опубликовано: |
MDPI AG
2022-11-01
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Серии: | Pharmaceutics |
Предметы: | |
Online-ссылка: | https://www.mdpi.com/1999-4923/14/11/2398 |