Itraconazole Amorphous Solid Dispersion Tablets: Formulation and Compaction Process Optimization Using Quality by Design Principles and Tools

BCS Class II drugs, such as itraconazole (ITZ), exhibit poor solubility (1–4 ng/mL) and so require solubility enhancement. Therefore, ITZ and Kollidon<sup>®</sup> VA64 (KOL) amorphous solid dispersions (ASDs) were produced using hot-melt extrusion (HME) to improve ITZ’s poor solubility....

Полное описание

Библиографические подробности
Главные авторы: Hetvi Triboandas, Kendal Pitt, Mariana Bezerra, Delphine Ach-Hubert, Walkiria Schlindwein
Формат: Статья
Язык:English
Опубликовано: MDPI AG 2022-11-01
Серии:Pharmaceutics
Предметы:
Online-ссылка:https://www.mdpi.com/1999-4923/14/11/2398