Nano and Microtechnologies for the Delivery of Oligonucleotides with Gene Silencing Properties

Oligonucleotides (ONs) are synthetic fragments of nucleic acid designed to modulate the expression of target proteins. DNA-based ONs (antisense, antigene, aptamer or decoy) and more recently a new class of RNA-based ONs, the small interfering RNAs (siRNAs), have gained great attention for the treatm...

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Bibliographic Details
Main Authors: Giuseppe De Rosa, Maria Immacolata La Rotonda
Format: Article
Language:English
Published: MDPI AG 2009-07-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/14/8/2801/