<i>In Silico</i> Identification of Natural Product-Based Inhibitors Targeting IL-1β/IL-1R Protein–Protein Interface

<i>In Silico</i> Identification of Natural Product-Based Inhibitors Targeting IL-1β/IL-1R Protein–Protein Interface

IL-1β mediates inflammation and regulates immune responses, cell proliferation, and differentiation. Dysregulation of IL-1β is linked to inflammatory and autoimmune diseases. Elevated IL-1β levels are found in patients with severe COVID-19, indicating its excessive production may worsen the disease....

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Bibliographic Details
Main Authors: Ting-ting Liu, Yan-kun Chen, Muhammad Adil, Mazen Almehmadi, Fahad M. Alshabrmi, Mamdouh Allahyani, Ahad Amer Alsaiari, Pei Liu, Muhammad Raheel Khan, Qinghua Peng
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Molecules
Subjects:
IL-1β
virtual screening
molecular docking
MD simulation
natural products
Online Access:https://www.mdpi.com/1420-3049/28/13/4885

Internet

https://www.mdpi.com/1420-3049/28/13/4885

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