Hydroxyurea Induces Bone Marrow Mesenchymal Stromal Cells Senescence and Modifies Cell Functionality In Vitro

Hydroxyurea Induces Bone Marrow Mesenchymal Stromal Cells Senescence and Modifies Cell Functionality In Vitro

Hydroxyurea (HU) is an antineoplastic agent that functions as an antimetabolite compound by inhibiting the ribonucleotide reductase. HU acts mainly as a cytostatic drug that through DNA replication stress may trigger a premature senescence-like cell phenotype, though its influence on bone marrow-der...

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Bibliographic Details
Main Authors: Sunčica Kapor, Milica Vukotić, Tijana Subotički, Dragoslava Đikić, Olivera Mitrović Ajtić, Milica Radojković, Vladan P. Čokić, Juan F. Santibanez
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Journal of Personalized Medicine
Subjects:
hydroxyurea
bone marrow mesenchymal stem cells
senescence
differentiation
immunosuppression
Online Access:https://www.mdpi.com/2075-4426/11/11/1048

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https://www.mdpi.com/2075-4426/11/11/1048

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