Associations between sex, body mass index and the individual microglial response in Alzheimer’s disease

Associations between sex, body mass index and the individual microglial response in Alzheimer’s disease

Abstract Background and objectives 18-kDa translocator protein position-emission-tomography (TSPO-PET) imaging emerged for in vivo assessment of neuroinflammation in Alzheimer’s disease (AD) research. Sex and obesity effects on TSPO-PET binding have been reported for cognitively normal humans (CN),...

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Bibliographic Details
Main Authors: Gloria Biechele, Boris-Stephan Rauchmann, Daniel Janowitz, Katharina Buerger, Nicolai Franzmeier, Endy Weidinger, Selim Guersel, Sebastian Schuster, Anika Finze, Stefanie Harris, Simon Lindner, Nathalie L. Albert, Christian Wetzel, Rainer Rupprecht, Axel Rominger, Carla Palleis, Sabrina Katzdobler, Lena Burow, Carolin Kurz, Mirlind Zaganjori, Lena-Katharina Trappmann, Oliver Goldhardt, Timo Grimmer, Jan Haeckert, Daniel Keeser, Sophia Stoecklein, Estrella Morenas-Rodriguez, Peter Bartenstein, Johannes Levin, Günter U. Höglinger, Mikael Simons, Robert Perneczky, Matthias Brendel
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
TSPO
Amyloid
Tau
Sex differences
Online Access:https://doi.org/10.1186/s12974-024-03020-y

Internet

https://doi.org/10.1186/s12974-024-03020-y

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