The autoimmunity risk variant LYP-W620 cooperates with CSK in the regulation of TCR signaling.

The autoimmunity risk variant LYP-W620 cooperates with CSK in the regulation of TCR signaling.

The protein tyrosine phosphatase LYP, a key regulator of TCR signaling, presents a single nucleotide polymorphism, C1858T, associated with several autoimmune diseases such as type I diabetes, rheumatoid arthritis, and lupus. This polymorphism changes an R by a W in the P1 Pro rich motif of LYP, whic...

Full description

Bibliographic Details
Main Authors: María Luisa de la Puerta, Antonio G Trinidad, María del Carmen Rodríguez, José María de Pereda, Mariano Sánchez Crespo, Yolanda Bayón, Andrés Alonso
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3554717?pdf=render

Internet

http://europepmc.org/articles/PMC3554717?pdf=render

Similar Items