First insight into the whole-genome sequence variations in Mycobacterium bovis BCG-1 (Russia) vaccine seed lots and their progeny clinical isolates from children with BCG-induced adverse events

First insight into the whole-genome sequence variations in Mycobacterium bovis BCG-1 (Russia) vaccine seed lots and their progeny clinical isolates from children with BCG-induced adverse events

Abstract Background The only licensed live Bacille Calmette-Guérin (BCG) vaccine used to prevent severe childhood tuberculosis comprises genetically divergent strains with variable protective efficacy and rates of BCG-induced adverse events. The whole-genome sequencing (WGS) allowed evaluating the g...

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Bibliographic Details
Main Authors: Olga Narvskaya, Daria Starkova, Diana Levi, Natalia Alexandrova, Vladimir Molchanov, Ekaterina Chernyaeva, Anna Vyazovaya, Alexander Mushkin, Viacheslav Zhuravlev, Natalia Solovieva, Boris Vishnevskiy, Igor Mokrousov
Format: Article
Language:English
Published: BMC 2020-08-01
Series:BMC Genomics
Subjects:
BCG
M. bovis BCG-1 (Russia)
Seed lot
Clinical isolate
Osteitis
Whole-genome sequencing
Online Access:http://link.springer.com/article/10.1186/s12864-020-06973-5

Internet

http://link.springer.com/article/10.1186/s12864-020-06973-5

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