Reference-Grade Genome and Large Linear Plasmid of Streptomyces rimosus: Pushing the Limits of Nanopore Sequencing

Reference-Grade Genome and Large Linear Plasmid of Streptomyces rimosus: Pushing the Limits of Nanopore Sequencing

ABSTRACT Streptomyces rimosus ATCC 10970 is the parental strain of industrial strains used for the commercial production of the important antibiotic oxytetracycline. As an actinobacterium with a large linear chromosome containing numerous long repeat regions, high GC content, and a single giant line...

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Bibliographic Details
Main Authors: Lucija Slemc, Jernej Jakše, Alessandro Filisetti, Damir Baranasic, Antonio Rodríguez-García, Francesco Del Carratore, Stefano Maria Marino, Jurica Zucko, Antonio Starcevic, Martin Šala, Mercedes Pérez-Bonilla, Marina Sánchez-Hidalgo, Ignacio González, Fernando Reyes, Olga Genilloud, Vicki Springthorpe, Dušan Goranovič, Gregor Kosec, Gavin H. Thomas, Davide De Lucrezia, Hrvoje Petković, Miha Tome
Format: Article
Language:English
Published: American Society for Microbiology 2022-04-01
Series:Microbiology Spectrum
Subjects:
Oxford Nanopore sequencing
Streptomyces rimosus
biosynthetic gene clusters
genome
linear plasmid
oxytetracycline
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02434-21

Internet

https://journals.asm.org/doi/10.1128/spectrum.02434-21

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