Gypenosides ameliorate high-fat diet-induced non-alcoholic steatohepatitis via farnesoid X receptor activation

Gypenosides ameliorate high-fat diet-induced non-alcoholic steatohepatitis via farnesoid X receptor activation

BackgroundGypenosides (Gyps), the major botanical component of Gynostemma pentaphyllum, was found to up-regulate the farnesoid X receptor (FXR) in a mouse model of non-alcoholic steatohepatitis (NASH). However, the exact role of FXR and underlying mechanisms in Gyps-mediated effects on NASH remain t...

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Bibliographic Details
Main Authors: Hongshan Li, Yingfei Xi, Hongliang Liu, Xin Xin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Nutrition
Subjects:
farnesoid X receptor
gypenosides
high-fat diet
non-alcoholic steatohepatitis
mice
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2022.914079/full

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https://www.frontiersin.org/articles/10.3389/fnut.2022.914079/full

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