Radical and lunatic fringes modulate notch ligands to support mammalian intestinal homeostasis

Radical and lunatic fringes modulate notch ligands to support mammalian intestinal homeostasis

Notch signalling maintains stem cell regeneration at the mouse intestinal crypt base and balances the absorptive and secretory lineages in the upper crypt and villus. Here we report the role of Fringe family of glycosyltransferases in modulating Notch activity in the two compartments. At the crypt b...

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Bibliographic Details
Main Authors: Preetish Kadur Lakshminarasimha Murthy, Tara Srinivasan, Matthew S Bochter, Rui Xi, Anastasia Kristine Varanko, Kuei-Ling Tung, Fatih Semerci, Keli Xu, Mirjana Maletic-Savatic, Susan E Cole, Xiling Shen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-04-01
Series:eLife
Subjects:
Fringe
Glycosylation
Notch Signalling
Intestinal Crypts
Lgr5+ Stem Cell
Online Access:https://elifesciences.org/articles/35710

Internet

https://elifesciences.org/articles/35710

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