Radical and lunatic fringes modulate notch ligands to support mammalian intestinal homeostasis
Notch signalling maintains stem cell regeneration at the mouse intestinal crypt base and balances the absorptive and secretory lineages in the upper crypt and villus. Here we report the role of Fringe family of glycosyltransferases in modulating Notch activity in the two compartments. At the crypt b...
Main Authors: | Preetish Kadur Lakshminarasimha Murthy, Tara Srinivasan, Matthew S Bochter, Rui Xi, Anastasia Kristine Varanko, Kuei-Ling Tung, Fatih Semerci, Keli Xu, Mirjana Maletic-Savatic, Susan E Cole, Xiling Shen |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2018-04-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/35710 |
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