DNA damage response-related immune activation signature predicts the response to immune checkpoint inhibitors: from gastrointestinal cancer analysis to pan-cancer validation

DNA damage response-related immune activation signature predicts the response to immune checkpoint inhibitors: from gastrointestinal cancer analysis to pan-cancer validation

Objective: DNA damage response (DDR) deficiency has emerged as a prominent determinant of tumor immunogenicity. This study aimed to construct a DDR-related immune activation (DRIA) signature and evaluate the predictive accuracy of the DRIA signature for response to immune checkpoint inhibitor (ICI)...

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Bibliographic Details
Main Authors: Junya Yan, Shibo Wang, Jing Zhang, Qiangqiang Yuan, Xianchun Gao, Nannan Zhang, Yan Pan, Haohao Zhang, Kun Liu, Jun Yu, Linbin Lu, Hui Liu, Xiaoliang Gao, Sheng Zhao, Wenyao Zhang, Abudurousuli Reyila, Yu Qi, Qiujin Zhang, Shundong Cang, Yuanyuan Lu, Yanglin Pan, Yan Kong, Yongzhan Nie
Format: Article
Language:English
Published: China Anti-Cancer Association 2024-03-01
Series:Cancer Biology & Medicine
Subjects:
dna damage response-related immune activation
immune checkpoint inhibitors
biomarker
gastrointestinal cancer
pan-cancer
Online Access:https://www.cancerbiomed.org/content/21/3/252

Internet

https://www.cancerbiomed.org/content/21/3/252

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