[68Ga]Ga-DOTA-Siglec-9 Detects Pharmacodynamic Changes of FAP-Targeted IL2 Variant Immunotherapy in B16-FAP Melanoma Mice

[68Ga]Ga-DOTA-Siglec-9 Detects Pharmacodynamic Changes of FAP-Targeted IL2 Variant Immunotherapy in B16-FAP Melanoma Mice

Vascular adhesion protein-1 (VAP-1) is an inflammation-inducible adhesion molecule, which supports contact between leukocytes and inflamed endothelium. There is evidence that VAP-1 is involved in the recruitment of leukocytes to melanoma tumors. Interleukin-2 (IL-2)-based immunotherapy is an efficie...

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Bibliographic Details
Main Authors: Riikka Viitanen, Helena Virtanen, Heidi Liljenbäck, Olli Moisio, Xiang-Guo Li, Valeria Nicolini, Marine Richard, Christian Klein, Tapan Nayak, Sirpa Jalkanen, Anne Roivainen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
immunocytokine
melanoma
PET
fibroblast activation protein
interleukin 2 (IL-2)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.901693/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.901693/full

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