Development of a Rapid Mass Spectrometric Determination of AMP and Cyclic AMP for PDE3 Activity Study: Application and Computational Analysis for Evaluating the Effect of a Novel 2-oxo-1,2-dihydropyridine-3-carbonitrile Derivative as PDE-3 Inhibitor

Development of a Rapid Mass Spectrometric Determination of AMP and Cyclic AMP for PDE3 Activity Study: Application and Computational Analysis for Evaluating the Effect of a Novel 2-oxo-1,2-dihydropyridine-3-carbonitrile Derivative as PDE-3 Inhibitor

A simple, quick, easy and cheap tandem mass spectrometry (MS/MS) method for the determination of adenosine monophosphate (AMP) and cyclic adenosine monophosphate (cAMP) has been newly developed. This novel MS/MS method was applied for the evaluation of the inhibitory effect of a novel 2-oxo-1,2-dihy...

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Bibliographic Details
Main Authors: Ilaria Cicalini, Barbara De Filippis, Nicola Gambacorta, Antonio Di Michele, Silvia Valentinuzzi, Alessandra Ammazzalorso, Alice Della Valle, Rosa Amoroso, Orazio Nicolotti, Piero Del Boccio, Letizia Giampietro
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Molecules
Subjects:
phosphodiesterases activity
AMP
cyclic AMP
tandem mass spectrometry
dihydropyridine
docking studies
Online Access:https://www.mdpi.com/1420-3049/25/8/1817

Internet

https://www.mdpi.com/1420-3049/25/8/1817

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