Pharmacodynamics of the Glutamate Receptor Antagonists in the Rat Barrel Cortex

Epipial application is one of the approaches for drug delivery into the cortex. However, passive diffusion of epipially applied drugs through the cortical depth may be slow, and different drug concentrations may be achieved at different rates across the cortical depth. Here, we explored the pharmaco...

Full description

Bibliographic Details
Main Authors: Daria Vinokurova, Andrey V. Zakharov, Julia Lebedeva, Gulshat F. Burkhanova, Kseniya A. Chernova, Nailya Lotfullina, Rustem Khazipov, Guzel Valeeva
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00698/full