The platinum coordination complex inhibits cell invasion-migration and epithelial-to-mesenchymal transition by altering the TGF-β-SMAD pathway in colorectal cancer

The platinum coordination complex inhibits cell invasion-migration and epithelial-to-mesenchymal transition by altering the TGF-β-SMAD pathway in colorectal cancer

Introduction: There is a steady increase in colorectal cancer (CRC) incidences worldwide; at diagnosis, about 20 percent of cases show metastases. The transforming growth factor-beta (TGF-β) signaling pathway is one of the critical pathways that influence the expression of cadherins allowing the epi...

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Bibliographic Details
Main Authors: Maha-Hamadien Abdulla, Aminah Ahmad Alzailai, Mansoor-Ali Vaali-Mohammed, Rehan Ahmad, Sabiha Fatima, Ahmed Zubaidi, Thamer bin Traiki, Amer Mahmood, Reem Hamoud Alrashoudi, Zahid Khan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Pharmacology
Subjects:
platinum
colorectal cancer
epithelial-to-mesenchymal transition
metastasis
TGF-β
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1178190/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1178190/full

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