Drug Discovery and Repurposing Inhibits a Major Gut Pathogen-Derived Oncogenic Toxin

Drug Discovery and Repurposing Inhibits a Major Gut Pathogen-Derived Oncogenic Toxin

Objective: The human intestinal microbiome plays an important role in inflammatory bowel disease (IBD) and colorectal cancer (CRC) development. One of the first discovered bacterial mediators involves Bacteroides fragilis toxin (BFT, also named as fragilysin), a metalloprotease encoded by enterotoxi...

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Bibliographic Details
Main Authors: Paul Metz, Martijn J. H. Tjan, Shaoguang Wu, Mehrosh Pervaiz, Susanne Hermans, Aishwarya Shettigar, Cynthia L. Sears, Tina Ritschel, Bas E. Dutilh, Annemarie Boleij
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
computational drug design and discovery
bacterial toxin
colorectal cancer
inflammatory bowel disease (IBD)
Bacteroides fragilis enterotoxin
enterotoxigenic Bacteroides fragilis (ETBF)
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2019.00364/full

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https://www.frontiersin.org/article/10.3389/fcimb.2019.00364/full

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