MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer

MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer

MUC1-C is overexpressed in castration-resistant prostate cancer and neuroendocrine prostate cancer. Here, the authors show that MUC1-C drives lineage plasticity through MYC and BRN2, inducing neuroendocrine features and stemness in prostate cancer.

Bibliographic Details
Main Authors: Yota Yasumizu, Hasan Rajabi, Caining Jin, Tsuyoshi Hata, Sean Pitroda, Mark D. Long, Masayuki Hagiwara, Wei Li, Qiang Hu, Song Liu, Nami Yamashita, Atsushi Fushimi, Ling Kui, Mehmet Samur, Masaaki Yamamoto, Yan Zhang, Ning Zhang, Deli Hong, Takahiro Maeda, Takeo Kosaka, Kwok K. Wong, Mototsugu Oya, Donald Kufe
Format: Article
Language:English
Published: Nature Portfolio 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-14219-6

Internet

https://doi.org/10.1038/s41467-019-14219-6

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