Pharmacological inhibition of hematopoietic progenitor kinase 1 positively regulates T-cell function.

Pharmacological inhibition of hematopoietic progenitor kinase 1 positively regulates T-cell function.

Hematopoietic progenitor kinase 1 (HPK1), a hematopoietic cell-specific Ste20-related serine/threonine kinase, is a negative regulator of signal transduction in immune cells, including T cells, B cells, and dendritic cells (DCs). In mice, HPK1 deficiency subverts inhibition of the anti-tumor immune...

Full description

Bibliographic Details
Main Authors: Yun Wang, Kelvin Zhang, Peter Georgiev, Steven Wells, Haiyan Xu, Brian M Lacey, Zangwei Xu, Jason Laskey, Robbie Mcleod, Joey L Methot, Mark Bittinger, Alexander Pasternak, Sheila Ranganath
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0243145

Internet

https://doi.org/10.1371/journal.pone.0243145

Similar Items