Seriniquinones as Therapeutic Leads for Treatment of BRAF and NRAS Mutant Melanomas

Seriniquinones as Therapeutic Leads for Treatment of BRAF and NRAS Mutant Melanomas

Isolated from the marine bacteria <i>Serinicoccus</i> sp., seriniquinone (<b>SQ1</b>) has been characterized by its selective activity in melanoma cell lines marked by its modulation of human dermcidin and induction of autophagy and apoptosis. While an active lead, the lack o...

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Bibliographic Details
Main Authors: Amanda S. Hirata, Paula Rezende-Teixeira, João Agostinho Machado-Neto, Paula C. Jimenez, James J. La Clair, William Fenical, Leticia V. Costa-Lotufo
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Molecules
Subjects:
natural products
drug discovery
marine pharmacology
antitumor agent
dermcidin
autophagy
Online Access:https://www.mdpi.com/1420-3049/26/23/7362

Internet

https://www.mdpi.com/1420-3049/26/23/7362

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