THE SYNTHESIS OF RGDF MIMETIC DERIVATIVES BASED ON 4-(ISOINDOLINE-5-YL)AMINO-4-OXOBUTYRIC ACID WITH THE ORAL ANTIAGGREGATIVE ACTIVITY
Ethyl ethers of N-[4-(isoindoline-5-yl)amino-4-oxobutyryl]-D,L-β-substituted-β-alanines were synthesized. Estimation of antiaggregatory activity of the compounds obtained has showed that the compounds possess an oral activity ex vivoin mice with the use of human rich platelet plasma.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Odessa I. I. Mechnikov National University
2015-03-01
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| Series: | Vìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Hìmìâ |
| Subjects: | |
| Online Access: | http://heraldchem.onu.edu.ua/article/view/40109 |