Atherosis-associated lnc_000048 activates PKR to enhance STAT1-mediated polarization of THP-1 macrophages to M1 phenotype

Atherosis-associated lnc_000048 activates PKR to enhance STAT1-mediated polarization of THP-1 macrophages to M1 phenotype

Our previous study has demonstrated that lnc_000048 is upregulated in large-artery atherosclerotic stroke and promotes atherosclerosis in ApoE–/– mice. However, little is known about the role of lnc_000048 in classically activated macrophage (M1) polarization. In this study, we established THP-1-der...

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Bibliographic Details
Main Authors: Yuanyuan Ding, Yu Sun, Hongyan Wang, Hongqin Zhao, Ruihua Yin, Meng Zhang, Xudong Pan, Xiaoyan Zhu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-01-01
Series:Neural Regeneration Research
Subjects:
atherosclerosis; inflammation; lnc_000048; lncrna; macrophage; polarization; protein kinase rna-activated (pkr); stat1
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=11;spage=2488;epage=2498;aulast=

Internet

http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=11;spage=2488;epage=2498;aulast=

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