The kleisin subunit controls the function of C. elegans meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1

The kleisin subunit controls the function of C. elegans meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1

The cohesin complex plays essential roles in chromosome segregation, 3D genome organisation, and DNA damage repair through its ability to modify DNA topology. In higher eukaryotes, meiotic chromosome function, and therefore fertility, requires cohesin complexes containing meiosis-specific kleisin su...

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Bibliographic Details
Main Authors: Maikel Castellano-Pozo, Georgios Sioutas, Consuelo Barroso, Josh P Prince, Pablo Lopez-Jimenez, Joseph Davy, Angel-Luis Jaso-Tamame, Oliver Crawley, Nan Shao, Jesus Page, Enrique Martinez-Perez
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-08-01
Series:eLife
Subjects:
meiosis
cohesin
sister chromatid cohesion
WAPL
SCC-2
Online Access:https://elifesciences.org/articles/84138

Internet

https://elifesciences.org/articles/84138

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