Hsc70-4 aggravates PolyQ-mediated neurodegeneration by modulating NF-κB mediated immune response in Drosophila

Hsc70-4 aggravates PolyQ-mediated neurodegeneration by modulating NF-κB mediated immune response in Drosophila

Huntington’s disease occurs when the stretch of CAG repeats in exon 1 of the huntingtin (htt) gene crosses the permissible limit, causing the mutated protein (mHtt) to form insoluble aggregates or inclusion bodies. These aggregates are non-typically associated with various essential proteins in the...

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Bibliographic Details
Main Authors: Saurabh Rai, Madhu G. Tapadia
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
HSPA8
PolyQ
Neurodegeneration
NF-κB
Relish
Immune response
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.857257/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.857257/full

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