Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections

Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections

Live attenuated influenza vaccines (LAIV) induce CD8+ T lymphocyte responses that play an important role in killing virus-infected cells. Despite the relative conservation of internal influenza A proteins, the epitopes recognized by T cells can undergo drift under immune pressure. The internal prote...

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Bibliographic Details
Main Authors: D. Korenkov, T. H. O. Nguyen, I. Isakova-Sivak, T. Smolonogina, L. E. Brown, K. Kedzierska, L. Rudenko
Format: Article
Language:English
Published: Taylor & Francis Group 2018-04-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
antigenic escape
influenza
laiv
nucleoprotein
t cell epitope
Online Access:http://dx.doi.org/10.1080/21645515.2017.1417713

Internet

http://dx.doi.org/10.1080/21645515.2017.1417713

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