Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections
Live attenuated influenza vaccines (LAIV) induce CD8+ T lymphocyte responses that play an important role in killing virus-infected cells. Despite the relative conservation of internal influenza A proteins, the epitopes recognized by T cells can undergo drift under immune pressure. The internal prote...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-04-01
|
| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2017.1417713 |
| _version_ | 1797677525259780096 |
|---|---|
| author | D. Korenkov T. H. O. Nguyen I. Isakova-Sivak T. Smolonogina L. E. Brown K. Kedzierska L. Rudenko |
| author_facet | D. Korenkov T. H. O. Nguyen I. Isakova-Sivak T. Smolonogina L. E. Brown K. Kedzierska L. Rudenko |
| author_sort | D. Korenkov |
| collection | DOAJ |
| description | Live attenuated influenza vaccines (LAIV) induce CD8+ T lymphocyte responses that play an important role in killing virus-infected cells. Despite the relative conservation of internal influenza A proteins, the epitopes recognized by T cells can undergo drift under immune pressure. The internal proteins of Russian LAIVs are derived from the master donor virus A/Leningrad/134/17/57 (Len/17) isolated 60 years ago and as such, some CD8+ T cell epitopes may vary between the vaccine and circulating wild-type strains. To partially overcome this issue, the nucleoprotein (NP) gene of wild-type virus can be incorporated into LAIV reassortant virus, along with the HA and NA genes. The present study compares the human CD8+ T cell memory responses to H3N2 LAIVs with the Len/17 or the wild-type NP using an in vitro model. |
| first_indexed | 2024-03-11T22:46:26Z |
| format | Article |
| id | doaj.art-123a7e3bb6a44b388512143f9d0437af |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:46:26Z |
| publishDate | 2018-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-123a7e3bb6a44b388512143f9d0437af2023-09-22T08:17:53ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2018-04-0114494194610.1080/21645515.2017.14177131417713Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infectionsD. Korenkov0T. H. O. Nguyen1I. Isakova-Sivak2T. Smolonogina3L. E. Brown4K. Kedzierska5L. Rudenko6Institute of Experimental MedicineUniversity of Melbourne, at The Peter Doherty Institute for Infection & ImmunityInstitute of Experimental MedicineInstitute of Experimental MedicineUniversity of Melbourne, at The Peter Doherty Institute for Infection & ImmunityUniversity of Melbourne, at The Peter Doherty Institute for Infection & ImmunityInstitute of Experimental MedicineLive attenuated influenza vaccines (LAIV) induce CD8+ T lymphocyte responses that play an important role in killing virus-infected cells. Despite the relative conservation of internal influenza A proteins, the epitopes recognized by T cells can undergo drift under immune pressure. The internal proteins of Russian LAIVs are derived from the master donor virus A/Leningrad/134/17/57 (Len/17) isolated 60 years ago and as such, some CD8+ T cell epitopes may vary between the vaccine and circulating wild-type strains. To partially overcome this issue, the nucleoprotein (NP) gene of wild-type virus can be incorporated into LAIV reassortant virus, along with the HA and NA genes. The present study compares the human CD8+ T cell memory responses to H3N2 LAIVs with the Len/17 or the wild-type NP using an in vitro model.http://dx.doi.org/10.1080/21645515.2017.1417713antigenic escapeinfluenzalaivnucleoproteint cell epitope |
| spellingShingle | D. Korenkov T. H. O. Nguyen I. Isakova-Sivak T. Smolonogina L. E. Brown K. Kedzierska L. Rudenko Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections Human Vaccines & Immunotherapeutics antigenic escape influenza laiv nucleoprotein t cell epitope |
| title | Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections |
| title_full | Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections |
| title_fullStr | Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections |
| title_full_unstemmed | Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections |
| title_short | Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections |
| title_sort | live attenuated influenza vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza cd8 t cells more relevant to current infections |
| topic | antigenic escape influenza laiv nucleoprotein t cell epitope |
| url | http://dx.doi.org/10.1080/21645515.2017.1417713 |
| work_keys_str_mv | AT dkorenkov liveattenuatedinfluenzavaccinesengineeredtoexpressthenucleoproteinofarecentisolatestimulatehumaninfluenzacd8tcellsmorerelevanttocurrentinfections AT thonguyen liveattenuatedinfluenzavaccinesengineeredtoexpressthenucleoproteinofarecentisolatestimulatehumaninfluenzacd8tcellsmorerelevanttocurrentinfections AT iisakovasivak liveattenuatedinfluenzavaccinesengineeredtoexpressthenucleoproteinofarecentisolatestimulatehumaninfluenzacd8tcellsmorerelevanttocurrentinfections AT tsmolonogina liveattenuatedinfluenzavaccinesengineeredtoexpressthenucleoproteinofarecentisolatestimulatehumaninfluenzacd8tcellsmorerelevanttocurrentinfections AT lebrown liveattenuatedinfluenzavaccinesengineeredtoexpressthenucleoproteinofarecentisolatestimulatehumaninfluenzacd8tcellsmorerelevanttocurrentinfections AT kkedzierska liveattenuatedinfluenzavaccinesengineeredtoexpressthenucleoproteinofarecentisolatestimulatehumaninfluenzacd8tcellsmorerelevanttocurrentinfections AT lrudenko liveattenuatedinfluenzavaccinesengineeredtoexpressthenucleoproteinofarecentisolatestimulatehumaninfluenzacd8tcellsmorerelevanttocurrentinfections |