Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections
Live attenuated influenza vaccines (LAIV) induce CD8+ T lymphocyte responses that play an important role in killing virus-infected cells. Despite the relative conservation of internal influenza A proteins, the epitopes recognized by T cells can undergo drift under immune pressure. The internal prote...
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Format: | Article |
Language: | English |
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Taylor & Francis Group
2018-04-01
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Series: | Human Vaccines & Immunotherapeutics |
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Online Access: | http://dx.doi.org/10.1080/21645515.2017.1417713 |
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author | D. Korenkov T. H. O. Nguyen I. Isakova-Sivak T. Smolonogina L. E. Brown K. Kedzierska L. Rudenko |
author_facet | D. Korenkov T. H. O. Nguyen I. Isakova-Sivak T. Smolonogina L. E. Brown K. Kedzierska L. Rudenko |
author_sort | D. Korenkov |
collection | DOAJ |
description | Live attenuated influenza vaccines (LAIV) induce CD8+ T lymphocyte responses that play an important role in killing virus-infected cells. Despite the relative conservation of internal influenza A proteins, the epitopes recognized by T cells can undergo drift under immune pressure. The internal proteins of Russian LAIVs are derived from the master donor virus A/Leningrad/134/17/57 (Len/17) isolated 60 years ago and as such, some CD8+ T cell epitopes may vary between the vaccine and circulating wild-type strains. To partially overcome this issue, the nucleoprotein (NP) gene of wild-type virus can be incorporated into LAIV reassortant virus, along with the HA and NA genes. The present study compares the human CD8+ T cell memory responses to H3N2 LAIVs with the Len/17 or the wild-type NP using an in vitro model. |
first_indexed | 2024-03-11T22:46:26Z |
format | Article |
id | doaj.art-123a7e3bb6a44b388512143f9d0437af |
institution | Directory Open Access Journal |
issn | 2164-5515 2164-554X |
language | English |
last_indexed | 2024-03-11T22:46:26Z |
publishDate | 2018-04-01 |
publisher | Taylor & Francis Group |
record_format | Article |
series | Human Vaccines & Immunotherapeutics |
spelling | doaj.art-123a7e3bb6a44b388512143f9d0437af2023-09-22T08:17:53ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2018-04-0114494194610.1080/21645515.2017.14177131417713Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infectionsD. Korenkov0T. H. O. Nguyen1I. Isakova-Sivak2T. Smolonogina3L. E. Brown4K. Kedzierska5L. Rudenko6Institute of Experimental MedicineUniversity of Melbourne, at The Peter Doherty Institute for Infection & ImmunityInstitute of Experimental MedicineInstitute of Experimental MedicineUniversity of Melbourne, at The Peter Doherty Institute for Infection & ImmunityUniversity of Melbourne, at The Peter Doherty Institute for Infection & ImmunityInstitute of Experimental MedicineLive attenuated influenza vaccines (LAIV) induce CD8+ T lymphocyte responses that play an important role in killing virus-infected cells. Despite the relative conservation of internal influenza A proteins, the epitopes recognized by T cells can undergo drift under immune pressure. The internal proteins of Russian LAIVs are derived from the master donor virus A/Leningrad/134/17/57 (Len/17) isolated 60 years ago and as such, some CD8+ T cell epitopes may vary between the vaccine and circulating wild-type strains. To partially overcome this issue, the nucleoprotein (NP) gene of wild-type virus can be incorporated into LAIV reassortant virus, along with the HA and NA genes. The present study compares the human CD8+ T cell memory responses to H3N2 LAIVs with the Len/17 or the wild-type NP using an in vitro model.http://dx.doi.org/10.1080/21645515.2017.1417713antigenic escapeinfluenzalaivnucleoproteint cell epitope |
spellingShingle | D. Korenkov T. H. O. Nguyen I. Isakova-Sivak T. Smolonogina L. E. Brown K. Kedzierska L. Rudenko Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections Human Vaccines & Immunotherapeutics antigenic escape influenza laiv nucleoprotein t cell epitope |
title | Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections |
title_full | Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections |
title_fullStr | Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections |
title_full_unstemmed | Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections |
title_short | Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections |
title_sort | live attenuated influenza vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza cd8 t cells more relevant to current infections |
topic | antigenic escape influenza laiv nucleoprotein t cell epitope |
url | http://dx.doi.org/10.1080/21645515.2017.1417713 |
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