Polycomb-mediated silencing of miR-8 is required for maintenance of intestinal stemness in Drosophila melanogaster

Abstract Balancing maintenance of self-renewal and differentiation is a key property of adult stem cells. The epigenetic mechanisms controlling this balance remain largely unknown. Herein, we report that the Polycomb Repressive Complex 2 (PRC2) is required for maintenance of the intestinal stem cell...

Full description

Bibliographic Details
Main Authors: Zoe Veneti, Virginia Fasoulaki, Nikolaos Kalavros, Ioannis S. Vlachos, Christos Delidakis, Aristides G. Eliopoulos
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46119-9