Neutrophils and NADPH Oxidases Are Major Contributors to Mild but Not Severe Ischemic Acute Kidney Injury in Mice

Neutrophils and NADPH Oxidases Are Major Contributors to Mild but Not Severe Ischemic Acute Kidney Injury in Mice

Upregulation of free radical-generating NADPH oxidases (NOX), xanthine oxidoreductase (XOR), and neutrophil infiltration-induced, NOX2-mediated respiratory burst contribute to renal ischemia–reperfusion injury (IRI), but their roles may depend on the severity of IRI. We investigated the role of NOX,...

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Bibliographic Details
Main Authors: Csaba Révész, Tamás Kaucsár, Mária Godó, Krisztián Bocskai, Tibor Krenács, Attila Mócsai, Gábor Szénási, Péter Hamar
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:International Journal of Molecular Sciences
Subjects:
acute kidney injury
ischemia–reperfusion injury
reactive oxygen species
oxidative stress
NADPH oxidase
xanthine oxidoreductase
Online Access:https://www.mdpi.com/1422-0067/25/5/2948

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https://www.mdpi.com/1422-0067/25/5/2948

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