IL-9 Producing Tumor-Infiltrating Lymphocytes and Treg Subsets Drive Immune Escape of Tumor Cells in Non-Small Cell Lung Cancer

IL-9 Producing Tumor-Infiltrating Lymphocytes and Treg Subsets Drive Immune Escape of Tumor Cells in Non-Small Cell Lung Cancer

Although lung cancer is the leading cause of cancer deaths worldwide, the mechanisms how lung cancer cells evade the immune system remain incompletely understood. Here, we discovered IL-9-dependent signaling mechanisms that drive immune evasion in non-small cell lung cancer (NSCLC). We found increas...

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Bibliographic Details
Main Authors: Lisanne Heim, Zuqin Yang, Patrick Tausche, Katja Hohenberger, Mircea T. Chiriac, Julia Koelle, Carol-Immanuel Geppert, Katerina Kachler, Sarah Miksch, Anna Graser, Juliane Friedrich, Rakshin Kharwadkar, Ralf J. Rieker, Denis I. Trufa, Horia Sirbu, Markus F. Neurath, Mark H. Kaplan, Susetta Finotto
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
IL-9
immune escape
NSCLC
TIL
tumor immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.859738/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.859738/full

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