Eotaxin-1/CCL11 promotes cellular senescence in human-derived fibroblasts through pro-oxidant and pro-inflammatory pathways

Eotaxin-1/CCL11 promotes cellular senescence in human-derived fibroblasts through pro-oxidant and pro-inflammatory pathways

IntroductionEotaxin-1/CCL11 is a pivotal chemokine crucial for eosinophil homing to the lungs of asthmatic patients. Recent studies also suggest that CCL11 is involved in the aging process, as it is upregulated in elderly, and correlated with shorter telomere length in leukocytes from asthmatic chil...

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Bibliographic Details
Main Authors: Patrícia Lavandoski, Vinícius Pierdoná, Rafael Moura Maurmann, Lucas Kich Grun, Fatima T. C. R. Guma, Florencia María Barbé-Tuana
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
CCL11
eotaxin-1
senescence
fibroblasts
asthma
premature aging
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1243537/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1243537/full

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