Polydatin Ameliorates High Fructose-Induced Podocyte Oxidative Stress via Suppressing HIF-1α/NOX4 Pathway

Polydatin Ameliorates High Fructose-Induced Podocyte Oxidative Stress via Suppressing HIF-1α/NOX4 Pathway

Long-term high fructose intake drives oxidative stress, causing glomerular podocyte injury. Polydatin, isolated from Chinese herbal medicine <i>Polygonum cuspidatum</i>, is used as an antioxidant agent that protects kidney function. However, it remains unclear how polydatin prevents oxid...

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Bibliographic Details
Main Authors: Hong Ding, Chuanfeng Tang, Wei Wang, Ying Pan, Ruiqing Jiao, Lingdong Kong
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Pharmaceutics
Subjects:
polydatin
HIF-1α/NOX4 pathway
podocyte injury
high fructose
oxidative stress
Online Access:https://www.mdpi.com/1999-4923/14/10/2202

Internet

https://www.mdpi.com/1999-4923/14/10/2202

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