Sparstolonin B Reduces Estrogen-Dependent Proliferation in Cancer Cells: Possible Role of Ceramide and PI3K/AKT/mTOR Inhibition

Sparstolonin B Reduces Estrogen-Dependent Proliferation in Cancer Cells: Possible Role of Ceramide and PI3K/AKT/mTOR Inhibition

<b>Background:</b> The aim of this study was to determine the effect of Sparstolonin B (SsnB) on cell proliferation and apoptosis in human breast cancer (MCF-7) and human ovarian epithelial cancer (OVCAR-3) cell lines in the presence and absence of estradiol hemihydrate (ES). Phosphoinos...

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Bibliographic Details
Main Authors: Yağmur Dilber, Hanife Tuğçe Çeker, Aleyna Öztüzün, Bürke Çırçırlı, Esma Kırımlıoğlu, Zerrin Barut, Mutay Aslan
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Pharmaceuticals
Subjects:
Sparstolonin B
ceramide
apoptosis
PI3K
AKT
mTOR
Online Access:https://www.mdpi.com/1424-8247/17/12/1564

Internet

https://www.mdpi.com/1424-8247/17/12/1564

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