JAG1 overexpression contributes to Notch1 signaling and the migration of HTLV-1-transformed ATL cells

JAG1 overexpression contributes to Notch1 signaling and the migration of HTLV-1-transformed ATL cells

Abstract Background HTLV-1 is a retrovirus that infects over 20 million people worldwide and is responsible for the hematopoietic malignancy adult T cell leukemia (ATL). We previously demonstrated that Notch is constitutively activated in ATL cells. Activating genetic mutations were found in Notch;...

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Bibliographic Details
Main Authors: Marcia Bellon, Ramona Moles, Hassiba Chaib-Mezrag, Joanna Pancewicz, Christophe Nicot
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Journal of Hematology & Oncology
Subjects:
HTLV-I
ATL
Notch
JAG1
NF-κB
miR-124
Online Access:http://link.springer.com/article/10.1186/s13045-018-0665-6

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http://link.springer.com/article/10.1186/s13045-018-0665-6

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