G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation

G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation

Abstract Background The bone marrow niche supports hematopoietic cell development through intimate contact with multipotent stromal mesenchymal stem cells; however, the intracellular signaling, function, and regulation of such supportive niche cells are still being defined. Our study was designed to...

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Bibliographic Details
Main Authors: Jaime M. Brozowski, Roman G. Timoshchenko, D. Stephen Serafin, Brittney Allyn, Jessica Koontz, Emily M. Rabjohns, Rishi R. Rampersad, Yinshi Ren, Amanda M. Eudy, Taylor F. Harris, David Abraham, Daniel Mattox, Clinton T. Rubin, Matthew J. Hilton, Janet Rubin, Nancy L. Allbritton, Matthew J. Billard, Teresa K. Tarrant
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Stem Cell Research & Therapy
Subjects:
Bone marrow-derived mesenchymal stem cells
Mesenchymal stem cells
G protein-coupled receptors (GPCRs)
G protein-coupled receptor kinase 3 (GRK3)
Sphingosine-1-phosphate (S1P)
Sphingosine-1-phosphate receptor (S1PR)
Online Access:https://doi.org/10.1186/s13287-022-02715-4

Internet

https://doi.org/10.1186/s13287-022-02715-4

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