Myeloid-derived suppressor cells are associated with impaired Th1 and Th17 responses and severe pulmonary paracoccidioidomycosis which is reversed by anti-Gr1 therapy

Myeloid-derived suppressor cells are associated with impaired Th1 and Th17 responses and severe pulmonary paracoccidioidomycosis which is reversed by anti-Gr1 therapy

Previous studies on paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in Latin America, revealed that host immunity is tightly regulated by several suppressive mechanisms mediated by tolerogenic plasmacytoid dendritic cells, the enzyme 2,3 indoleamine dioxygenase (IDO-1), and regulat...

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Bibliographic Details
Main Authors: Nycolas Willian Preite, Valéria de Lima Kaminski, Bruno Montanari Borges, Vera Lúcia Garcia Calich, Flávio Vieira Loures
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
paracoccidioidomycosis (PCM)
MDSC (myeloid-derived suppressor cell)
immunoregulation
fungal infection
lung immune cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1039244/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1039244/full

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