Population pharmacokinetic modelling of primaquine exposures in lactating women and breastfed infants

Abstract Current guidelines advise against primaquine treatment for breastfeeding mothers to avoid the potential for haemolysis in infants with G6PD deficiency. To predict the haemolytic risk, the amount of drug received from the breast milk and the resulting infant drug exposure need to be characte...

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Bibliographic Details
Main Authors: Thanaporn Wattanakul, Mary Ellen Gilder, Rose McGready, Warunee Hanpithakpong, Nicholas P. J. Day, Nicholas J. White, François Nosten, Joel Tarning, Richard M. Hoglund
Format: Article
Language:English
Published: Nature Portfolio 2024-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-47908-y