SLIT/ROBO2 Signaling Promotes Mammary Stem Cell Senescence by Inhibiting Wnt Signaling

SLIT/ROBO2 Signaling Promotes Mammary Stem Cell Senescence by Inhibiting Wnt Signaling

WNT signaling stimulates the self-renewal of many types of adult stem cells, including mammary stem cells (MaSCs), but mechanisms that limit this activity are poorly understood. Here, we demonstrate that SLIT2 restricts stem cell renewal by signaling through ROBO2 in a subset of basal cells to negat...

Full description

Bibliographic Details
Main Authors: Gwyndolen Harburg, Jennifer Compton, Wei Liu, Naomi Iwai, Shahrzad Zada, Rebecca Marlow, Phyllis Strickland, Yi Arial Zeng, Lindsay Hinck
Format: Article
Language:English
Published: Elsevier 2014-09-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671114002379

Internet

http://www.sciencedirect.com/science/article/pii/S2213671114002379

Similar Items