Adaptive Immune Response Signaling Is Suppressed in Ly6Chigh Monocyte but Upregulated in Monocyte Subsets of ApoE-/- Mice — Functional Implication in Atherosclerosis

Adaptive Immune Response Signaling Is Suppressed in Ly6Chigh Monocyte but Upregulated in Monocyte Subsets of ApoE-/- Mice — Functional Implication in Atherosclerosis

RationaleInflammatory monocyte (MC) subset differentiation is a major feature in tissue inflammatory and atherosclerosis. The underlying molecular mechanism remains unclear.ObjectiveThis study aims to explore molecule targets and signaling which determinate immunological features in MC subsets.Metho...

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Bibliographic Details
Main Authors: Pingping Yang, Qinghua Wu, Lizhe Sun, Pu Fang, Lu Liu, Yong Ji, Joon-Young Park, Xuebin Qin, Xiaofeng Yang, Hong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Immunology
Subjects:
atherosclerosis
Ly6C MC
adaptive immune response
inflammatory
ApoE
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.809208/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.809208/full

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