Bitter melon extracts and cucurbitane-type triterpenoid glycosides antagonize lipopolysaccharide-induced inflammation via suppression of NLRP3 inflammasome

Bitter melon extracts and cucurbitane-type triterpenoid glycosides antagonize lipopolysaccharide-induced inflammation via suppression of NLRP3 inflammasome

Bitter melon (Momordica charantia L.) has been used to manage diabetes and various inflammatory conditions. While studies have explored the use of bitter melon to manage these conditions, the bioactive components and molecular mechanisms mediating the anti-inflammatory effects remain elusive. In the...

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Bibliographic Details
Main Authors: Jose L. Perez, Siddanagouda R. Shivanagoudra, Wilmer H. Perera, Da Mi Kim, Chia S. Wu, Yuxiang Sun, G.K. Jayaprakasha, Bhimanagouda S. Patil
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Journal of Functional Foods
Subjects:
Momordica charantia
Triterpenoids
Anti-inflammatory
Metabolic endotoxemia
Macrophages
Inflammasome
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464621003698

Internet

http://www.sciencedirect.com/science/article/pii/S1756464621003698

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