A pan-tumor-siRNA aptamer chimera to block nonsense-mediated mRNA decay inflames and suppresses tumor progression

A pan-tumor-siRNA aptamer chimera to block nonsense-mediated mRNA decay inflames and suppresses tumor progression

Immune-checkpoint blockade (ICB) therapy has changed the clinical outcome of many types of aggressive tumors, but there still remain many cancer patients that do not respond to these treatments. There is an unmet need to develop a feasible clinical therapeutic platform to increase the rate of respon...

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Bibliographic Details
Main Authors: Daniel Meraviglia-Crivelli, Helena Villanueva, Ashwathi Puravankara Menon, Angelina Zheleva, Beatriz Moreno, María Villalba-Esparza, Fernando Pastor
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
oligonucleotides: therapies and applications
aptamer
cancer immunotherapy
RNAi delivery
NMD
Online Access:http://www.sciencedirect.com/science/article/pii/S216225312200186X

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http://www.sciencedirect.com/science/article/pii/S216225312200186X

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