2027 The role of lysyl oxidase in systemic sclerosis-associated lung fibrosis

OBJECTIVES/SPECIFIC AIMS: Systemic sclerosis (SSc) is a connective tissue disease of unknown etiology characterized by progressive fibrosis of the skin and multiple visceral organs. Effective therapies for SSc are needed. Lysyl oxidase (LOX) is a copper-dependent amide oxidase that plays a critical...

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Bibliographic Details
Main Authors: Xinh-Xinh Nguyen, Tetsuya Nishimoto, Takahisa Takihara, Logan Mlakar, Ellen Riemer, Jonathan Heywood, Amy Bradshaw, Carol Feghali-Bostwick
Format: Article
Language:English
Published: Cambridge University Press 2018-06-01
Series:Journal of Clinical and Translational Science
Online Access:https://www.cambridge.org/core/product/identifier/S2059866118001383/type/journal_article