The Carboxy Terminal Region of the Human Cytomegalovirus Immediate Early 1 (IE1) Protein Disrupts Type II Inteferon Signaling

The Carboxy Terminal Region of the Human Cytomegalovirus Immediate Early 1 (IE1) Protein Disrupts Type II Inteferon Signaling

Interferons (IFNs) activate the first lines of defense against viruses, and promote innate and adaptive immune responses to viruses. We report that the immediate early 1 (IE1) protein of human cytomegalovirus (HCMV) disrupts signaling by IFNγ. The carboxyl-terminal region of IE1 is required for this...

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Bibliographic Details
Main Authors: Bindu Raghavan, Charles H. Cook, Joanne Trgovcich
Format: Article
Language:English
Published: MDPI AG 2014-04-01
Series:Viruses
Subjects:
human cytomegalovirus
interferons
interferon g
immediate early 1
IE1
STAT1
STAT2
ND10
antiviral defense
Online Access:http://www.mdpi.com/1999-4915/6/4/1502

Internet

http://www.mdpi.com/1999-4915/6/4/1502

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