Cell type and sex specific mitochondrial phenotypes in iPSC derived models of Alzheimer’s disease

Cell type and sex specific mitochondrial phenotypes in iPSC derived models of Alzheimer’s disease

IntroductionMitochondrial dysfunction is observed in Alzheimer’s disease (AD). Altered mitochondrial respiration, cytochrome oxidase (COX) Vmax, and mitophagy are observed in human subjects and animal models of AD. Models derived from induced pluripotent stem cells (iPSCs) may not recapitulate these...

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Bibliographic Details
Main Authors: Kaitlin Flannagan, Julia A. Stopperan, Brittany M. Hauger, Benjamin R. Troutwine, Colton R. Lysaker, Taylor A. Strope, Vivien Csikos Drummond, Caleb A. Gilmore, Natalie A. Swerdlow, Julia M. Draper, Cynthia M. Gouvion, Jay L. Vivian, Mohammad Haeri, Russell H. Swerdlow, Heather M. Wilkins
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
mitochondria
Alzheimer’s disease
neuron
astrocyte
induced pluripotent stem cell
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1201015/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2023.1201015/full

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