Tetraspanin CD82 interaction with cholesterol promotes extracellular vesicle–mediated release of ezrin to inhibit tumour cell movement

Tetraspanin CD82 interaction with cholesterol promotes extracellular vesicle–mediated release of ezrin to inhibit tumour cell movement

Tumour metastasis suppressor KAI1/CD82 inhibits tumour cell movement. As a transmembrane protein, tetraspanin CD82 bridges the interactions between membrane microdomains of lipid rafts and tetraspanin-enriched microdomains (TEMs). In this study, we found that CD82 and other tetraspanins contain chol...

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Bibliographic Details
Main Authors: Chao Huang, Franklin A. Hays, James J. Tomasek, Siribhinya Benyajati, Xin A. Zhang
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Journal of Extracellular Vesicles
Subjects:
tetraspanin
cholesterol
lipid raft
extracellular vesicle
cell movement
tumour invasiveness
Online Access:http://dx.doi.org/10.1080/20013078.2019.1692417

Internet

http://dx.doi.org/10.1080/20013078.2019.1692417

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