KLF1 directly activates expression of the novel fetal globin repressor ZBTB7A/LRF in erythroid cells

KLF1 directly activates expression of the novel fetal globin repressor ZBTB7A/LRF in erythroid cells

Abstract: Genes encoding the human β-like hemoglobin proteins undergo a developmental switch from fetal γ-globin to adult β-globin expression around the time of birth. β-hemoglobinopathies, such as sickle-cell disease and β-thalassemia, result from mutations affecting the adult β-globin gene. The on...

Full description

Bibliographic Details
Main Authors: Laura J. Norton, Alister P.W. Funnell, Jon Burdach, Beeke Wienert, Ryo Kurita, Yukio Nakamura, Sjaak Philipsen, Richard C.M. Pearson, Kate G.R. Quinlan, Merlin Crossley
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Blood Advances
Online Access:http://www.sciencedirect.com/science/article/pii/S2473952920301737

Internet

http://www.sciencedirect.com/science/article/pii/S2473952920301737

Similar Items