Next generation risk assessment: an ab initio case study to assess the systemic safety of the cosmetic ingredient, benzyl salicylate, after dermal exposure

Next generation risk assessment: an ab initio case study to assess the systemic safety of the cosmetic ingredient, benzyl salicylate, after dermal exposure

We performed an ab initio next-generation risk assessment (NGRA) for a fragrance ingredient, benzyl salicylate (BSal), to demonstrate how cosmetic ingredients can be evaluated for systemic toxicity endpoints based on non-animal approaches. New approach methodologies (NAMs) used to predict the intern...

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Bibliographic Details
Main Authors: Johanna Ebmeyer, Abdulkarim Najjar, Daniela Lange, Mareike Boettcher, Silja Voß, Katrin Brandmair, Jaqueline Meinhardt, Jochen Kuehnl, Nicola J. Hewitt, Christopher-Tilman Krueger, Andreas Schepky
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Pharmacology
Subjects:
cosmetic ingredients
new approach methodologies
benzyl salicylate
physiologically based pharmacokinetic modeling
ab initio safety assessment
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1345992/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2024.1345992/full

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