Antiproliferative Mechanisms of a Polyphenolic Combination of Kaempferol and Fisetin in Triple-Negative Breast Cancer Cells

Antiproliferative Mechanisms of a Polyphenolic Combination of Kaempferol and Fisetin in Triple-Negative Breast Cancer Cells

Herein, we investigate the combinatorial therapeutic effects of naturally occurring flavonoids kaempferol (K) and fisetin (F) on triple-negative breast cancer (TNBC: MDA-MB-231 cell line). Dose-dependent MTT assay results show that K and F exhibited cytotoxicity in MDA-MB-231 cells at 62 and 75 μM (...

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Bibliographic Details
Main Authors: Mohd. Afzal, Abdullah Alarifi, Abdalnaser Mahmoud Karami, Rashid Ayub, Naaser A. Y. Abduh, Waseem Sharaf Saeed, Mohd. Muddassir
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
breast cancer
flavonoids
kaempferol
fisetin
antioxidant
Online Access:https://www.mdpi.com/1422-0067/24/7/6393

Internet

https://www.mdpi.com/1422-0067/24/7/6393

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