Predicting Throughput and Melt Temperature in Pharmaceutical Hot Melt Extrusion

Predicting Throughput and Melt Temperature in Pharmaceutical Hot Melt Extrusion

Even though hot melt extrusion (HME) is a commonly applied process in the pharmaceutical area, determination of the optimal process parameters is demanding. The goal of this study was to find a rational approach for predetermining suitable extrusion parameters, with a focus on material temperature a...

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Bibliographic Details
Main Authors: Tobias Gottschalk, Cihangir Özbay, Tim Feuerbach, Markus Thommes
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Pharmaceutics
Subjects:
hot melt extrusion
solid dispersion
process parameter
quality by design
one dimensional
simulation
Online Access:https://www.mdpi.com/1999-4923/14/9/1757

Internet

https://www.mdpi.com/1999-4923/14/9/1757

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