Bidirectional ATP-driven transport of cobalamin by the mycobacterial ABC transporter BacA

Abstract BacA is a mycobacterial ATP-binding cassette (ABC) transporter involved in the translocation of water-soluble compounds across the lipid bilayer. Whole-cell-based assays have shown that BacA imports cobalamin as well as unrelated hydrophilic compounds such as the antibiotic bleomycin and th...

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Bibliographic Details
Main Authors: Mark Nijland, Solène N. Lefebvre, Chancievan Thangaratnarajah, Dirk J. Slotboom
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46917-1